今天是:2018年10月21日 欢迎您来到本站!!!您现在的位置是在人群中预先存在对抗甲型H1N1病毒的免疫力!!
 
用户名:
密码:
验证码:
新会员注册!
学会动态
· 我省免疫学会芦小单同志获得第四届中国免疫学会青年学者奖 2014-10-30
  10月19日至21日,中国免疫学会在济南举行了第九届全国学术大会,共2000余人参会。本次大会颁发了
· 关 于 收 取 中 国 免 疫 学 会 会 员 费 的 通 知 2013-12-9
 
第一届理事会
名誉理事长:
杨贵贞、朱 迅
理事长:谭岩
副理事长:毕胜利、李 一、李 勇、李玉新、金宁一、孟繁平、戴 绘
秘书长:方艳秋
副秘书长:李太元、许四平、杜 博、张逢春、鲍永利、李 昌
第二届理事会
名誉理事长:
李首一
理事长:谭岩
副理事长:方艳秋、毕胜利、李 一、李玉新、张庆镐、孟繁平、金宁一
秘书长:方艳秋
副秘书长:左红斌、李太元、李 昌、张逢春、许四平、杜 博、鲍永利
医学新闻 » 在人群中预先存在对抗甲型H1N
在人群中预先存在对抗甲型H1N1病毒的免疫力
点击率:4967   发布人:管理员    发布日期:2011-9-30

最近一期美国科学院学报上刊登Greenbaum等撰写的论文,文章通过调查和研究发现:在人群中预先存在对抗甲型H1N1病毒的免疫力。

Abstract

A major concern about the ongoing swine-origin H1N1 influenza virus (S-OIV) outbreak is that the virus may be so different from seasonal H1N1 that little immune protection exists in the human population. In this study, we examined the molecular basis for pre-existing immunity against S-OIV, namely the recognition of viral immune epitopes by T cells or B cells/antibodies that have been previously primed by circulating influenza strains. Using data from the Immune Epitope Database, we found that only 31% (8/26) of B-cell epitopes present in recently circulating H1N1 strains are conserved in the S-OIV, with only 17% (1/6) conserved in the hemagglutinin (HA) and neuraminidase (NA) surface proteins. In contrast, 69% (54/78) of the epitopes recognized by CD8+ T cells are completely invariant. We further demonstrate experimentally that some memory T-cell immunity against S-OIV is present in the adult population and that such memory is of similar magnitude as the pre-existing memory against seasonal H1N1 influenza. Because protection from infection is antibody mediated, a new vaccine based on the specific S-OIV HA and NA proteins is likely to be required to prevent infection. However, T cells are known to blunt disease severity. Therefore, the conservation of a large fraction of T-cell epitopes suggests that the severity of an S-OIV infection, as far as it is determined by susceptibility of the virus to immune attack, would not differ much from that of seasonal flu. These results are consistent with reports about disease incidence, severity, and mortality rates associated with human S-OIV.

原文链接:http://www.pnas.org/content/early/2009/11/13/0911580106.abstract?sid=929ded26-c04a-4902-a41d-55690cf54ea2

打印本页  关闭本页
   
 
中华人民共和国卫生部 吉林省卫生厅 吉林省人民医院 中国免疫学会(CSI) 吉林省生物治疗学会 中国免疫学杂志

版权所有:吉林省免疫学会 地址:长春市工农大路1183号 
 电话:0431-85595145 QQ: 2468732179  邮箱:2468732179@qq.com 网址:http://www.jlmy.org

网站支持:
新格网络技术